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Zerdeçalın içindeki maddeler
» 1,8-CINEOLE (kgv) 30-720 ppm
» 2-BORNANOL (bt)
» 2-HYDROXY-METHYL-ANTHRAQUINONE (kgv)
» 4-HYDROXY-CINNAMOYL-(FERULOYL)-METHANE (kgv) 180 ppm
» ALPHA-ATLANTONE (kgv)
» ALPHA-PINENE (ey) 5,300 ppm
» ALPHA-TERPINEOL (kgv)
» AR-TURMERONE (kgv) 5,800 ppm
» ARABINOSE (kgv) 10,000 ppm
» ASCORBIC-ACID (kgv) 0-293 ppm
» ASH (kgv) 9,000-148,000 ppm
» AZULENE (kgv)
» BAKIR (kgv) 6-17 ppm
» BETA-CAROTENE (kgv)
» BETA-PINENE (ey) 2,700 ppm
» BETA-SESQUIPHELLANDRENE (kgv)
» BIS-(PARA-HYDROXY-CINNAMOYL)-METHANE (kgv) 1,360 ppm
» BIS-DESMETHOXYCURCUMIN (kgv) 67-27,000 ppm
» BISABOLENE (Kök)
» BORNEOL (kgv)
» BORON (Kök) 1-6 ppm
» CAFFEIC-ACID (kgv) 5 ppm
» CAPRYLIC-ACID (kgv)
» CARBOHYDRATES (kgv) 79,000-829,000 ppm
» CARYOPHYLLENE (ey)
» ÇİNKO (kgv) 22 ppm
» CINEOLE (ey) 29,200 ppm
» CINNAMIC-ACID (kgv)
» COBALT (kgv) 1 ppm
» CUMINYL-ALCOHOL (kgv)
» CURCUMENE (ey) 121,700 ppm
» CURCUMENOL (ey) 21,300 ppm
» CURCUMIN (kgv) 9-38,888 ppm
» CURDIONE (ey) 11,900 ppm
» CURLONE (kgv) 120 ppm
» CURZERENONE (kgv)
» CURZERENONE-C (ey) 20,400 ppm
» CYCLO-ISOPRENEMYRCENE (kgv) 8,500-29,750 ppm
» D-ALPHA-PHELLANDRENE (kgv) 30-720 ppm
» D-CAMPHENE (kgv) 480 ppm
» D-CAMPHOR (kgv) 30-1,500 ppm
» D-SABINENE (kgv) 20-432 ppm
» DEHYDROTURMERONE (kgv)
» DEMİR (kgv) 121-467 ppm
» DESMETHOXYCURCUMIN (kgv) 500-11,100 ppm
» DI-P-COUMAROYL-METHANE (kgv)
» DICINNAMOYLMETHANE (kgv)
» DIDESMETHOXYCURCUMIN (kgv)
» DIDESMETHOXYCURCUMIN (kgv)
» DIFERULOYL-» METHANE (kgv)
» DIHYDROCURCUMIN (kgv) 57 ppm
» EO (kgv) 3,000-72,000 ppm
» EUGENOL (ey) 2,100 ppm
» FERULOYL-P-COUMAROYL-METHANE (kgv)
FOSFOR (kgv) 640-6,307 ppm
» FRUCTOSE (kgv) 120,000 ppm
» GAMMA-ATLANTONE (kgv)
» GLUCOSE (kgv) 280,000 ppm
» GUAIACOL (kgv)
» ISOBORNEOL (kgv) (ey) 200 ppm
» KROM (kgv) 6 ppm
» KALSİYUM(kgv) 270-2,898 ppm
» L-ALPHA-CURCUMENE (kgv) 18,000 ppm
» L-BETA-CURCUMENE (kgv) 18,000 ppm
» LIMONENE (ey) 2,300 ppm
» LİF(kgv) 9,000-84,000 ppm
» LINALOL (ey) 1,600 ppm
» MANGANESE (kgv) 33-78 ppm
» MONODESMETHOXYCURCUMIN (kgv)
» NIACIN (kgv) 5-62 ppm
» NICKEL (kgv) 3.8 ppm
» O-COUMARIC-ACID (yp)
» P-COUMARIC-ACID (kgv) 345 ppm
» P-CYMENE (kgv)
» P-METHOXYCINNAMIC-ACID (kgv) 360 ppm
» P-TOLYMETHYLCARBINOL (kgv) 500-1,750 ppm
» POTASSIUM (kgv) 4,870-41,271 ppm
» PROTEIN (kgv) 12,000-306,000 ppm
» PROTOCATECHUIC-ACID (yp)
» RESIN (kgv)
» RIBOFLAVIN (kgv) 0-12 ppm
» SODYUM (kgv) 30-4,290 ppm
» SU (kgv) 133,000 ppm
» SYRINGIC-ACID (yp)
» TERPINENE (ey) 27,200 ppm
» TERPINEOL (ey) 500 ppm
» THIAMIN (kgv) 0-8 ppm
» TURMERONE (kgv) 1,800-43,200 ppm
» UKONAN-A (kgv) 33-6,600 ppm
» UKONAN-B (kgv) 47 ppm
» UKONAN-C (kgv) 52 ppm
» UKONAN-D (kgv)
» VANILLIC-ACID (yp)
» YAÐ (kgv) 18,000-153,000 ppm
» ZINGIBERENE (kgv) 750-18,000 ppm
ppm = parts per million, tr = trace, (bt)= bitki, (ç)= çiçek, (ey)= esansiyal yağ, (kgv)= kök gövde, (th)= tohum, (yp)= yaprak
Çeşitli hastalıklarda zerdeçal
Antiioksidan/zerdeçal
Zerdeçal en etkin ve en yaygın kullanılan antioksidanlardan biridir(5-9).
Zerdeçal/enflamasyon
Yapılan araştırmalar zerdeçalın lökotirien, prostaglandin, tumor nekroze edici faktör ve interlökin-12 gibi iltihap oluşturan kimyasal maddelerin ortaya çıkışını geciktirip hafiflettiğini göstermiştir(10-11).
Solunum yolu enfeksiyonları/zerdeçal
Zerdeçal antienflamatuar ve antioksidan etkileri ile solunum yolu enfeksiyonlarınada (üst solunum yolu enfeksiyonu, astım, bronşit, sinüzit) yaygın olarak kullanılan bir halk ilacıdır.
Zerdeçal/kanser
Zerdeçalın aktif maddesi curcumin hem kanserin korunmasını sağlar hem de bazı kanserlerde tedavi edici olarak kullanılmıştır Tümör hücrelerinin üremesini engeller ve toksik yan ürünlerini azaltır (12-17).
Zerdaçal/Alzheimer
Zerdeçal antioksidan ve antienflamatuar etkileri ile Alzheimer hastalığına gidişi engellemektedir. Zerdeçalın beta-amiloid plaklarının gelişimini yavaşlattığı da gösterilmiştir (18-20).
Diğer hastalıklar
Zerdeçalın başta mültipl skleroz (21-22), katarakt oluşumu (23), karaciğer hasarı (24), enfarktüs(25) ve felç (26) olmak üzere çeşitli hastalıklar üzerine olumlu etkileri olduğuna ilişkin çok sayıda çalışma vardır.
Kaynaklar
1. Egan ME, Pearson P, Weiner SA, Rajendran V, Rubin D, Glöckner-Pagel J, Canny S, Du K, Lukacs GL, Caplan MJ. Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects Science, 2004; 304:600-602
2. Aydın A, Adal E. Kistik fibroz. İst Çocuk Kliniği Dergisi (Pediatri Arşivi) 1996; 3:308-13
3. Araujo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz. 2001 Jul;96(5):723-8.
4. http://www.bitki.org/index.php?bitki=curcuma%20longa
5. Miquel J, Bernd A, Sempere JM,Díaz-Alperi J, Ramírez A. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Archives of Gerontology and Geriatrics. 2002; 34(1): 37-46
6. Jitoe et al., 1992A. Jitoe, T. Masuda, I.G.P. Tengah, D.N. Suprapta, I.W. Gara and N. Nakatani , Antioxidant activity of tropical ginger extracts and analysis of the contained curcuminoids. J. Agric. Food Chem. 40 (1992), pp. 1337–1340.
7. Masuda et al., 1992T. Masuda, J. Isobe, A. Jitoe and N. Nakatani , Antioxidative curcuminoids from rhyzomes of Curcuma xantorrhyza. Phytochemistry 31 (1992), pp. 3645–3647. Abstract
8. Miquel J, Bernd A, Sempere JM,Díaz-Alperi J, Ramírez A. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Archives of Gerontology and Geriatrics. 2002; 34(1): 37-46
9. Ono K, Hasegawa K, Naiki H, Yamanda M. Curcumin has potent anti-amyloidogenic effects for Alzheimer’s beta-amyloid fibrils in vitro. J Neurosci Res. 2004 Mar 15; 75(6):742-50.
10. Skrzypezac-Jankun, N.P. McCabe, S.H. Selman and J. Jankun , Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence. Int. J. Mol. Med. 6 (2000), pp. 521–526.
11. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003 Feb;9(1):161-8.
12. Inano, M. Onoda, N. Inafuku, M. Kubota, Y. Kamada, T. Osawa, H. Kobayashi and K. Wakabayashi , Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis 21 (2000), pp. 1835–1841.
13. M.T. Huang, W. Ma, P. Yen, J.G. Xie, J. Han, K. Frenkel, D. Grunberger and A.H. Conney , Inhibitory effect of low doses of curcumin topical application on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis. Carcinogenesis 18 (1997), pp. 83–88.
14. Inano, M. Onoda, N. Inafuku, M. Kubota, Y. Kamada, T. Osawa, H. Kobayashi and K. Wakabayashi , Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis 21 (2000), pp. 1835–1841.
15. P. Limtrakul, S. Lipigorngoson, O. Namwong, A. Apisariyakul and F.W. Dunn , Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett. 116 (1997), pp. 197–203.
16. Van Erk MJ, Teuling E, Staal YCM et al. Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells. J Carcinog. 2004 May 12;3(1):8.
17. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003 Jan-Feb;23(1A):363-98.
18. Ambegaokar SS, Wu L, Alamshahi K, et al. Curcumin inhibits dose-dependently and time-dependently neuroglial cell proliferation and growth. Neuro Endocrinol Lett. 2003 Dec; 24(6): 469-73.
19. Frautschy SA, Hu W, Kim P, et al. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging. 2001 Nov; 22(6):993-1005.
20. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1;21(21):8370-7.
21. Natarajan C, Bright JJ. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J Immunol 2002;168(12):6506-13.
22. Natarajan C, Bright JJ. Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. Genes Immun 2002;3(2):59-70.
23. Padmaja S, Raju TN. Antioxidant effect of curcumin in selenium induced cataract of Wistar rats. Indian J Exp Biol. 2004;42(6):601-3.
24. Liu YG, Chen HC, Jiang YP. Protective effect of curcumin on experimental liver injury in mice. Zhongguo Zhong Yaho Za Zhi. 2003;28(8):756-8, 93.
25. Nirmala C, Puvanakrisnan R. Protective role of curcumin against isoproterenol induced myocardial infarction. Mol Cell Biochem. 1996 Jun 21;159(2):85-93.
26. Thiyagarajan M, Sharma SS. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sci. 2004 Jan 9;74(8):969-85.
Zerdeçalın içindeki maddeler
» 1,8-CINEOLE (kgv) 30-720 ppm
» 2-BORNANOL (bt)
» 2-HYDROXY-METHYL-ANTHRAQUINONE (kgv)
» 4-HYDROXY-CINNAMOYL-(FERULOYL)-METHANE (kgv) 180 ppm
» ALPHA-ATLANTONE (kgv)
» ALPHA-PINENE (ey) 5,300 ppm
» ALPHA-TERPINEOL (kgv)
» AR-TURMERONE (kgv) 5,800 ppm
» ARABINOSE (kgv) 10,000 ppm
» ASCORBIC-ACID (kgv) 0-293 ppm
» ASH (kgv) 9,000-148,000 ppm
» AZULENE (kgv)
» BAKIR (kgv) 6-17 ppm
» BETA-CAROTENE (kgv)
» BETA-PINENE (ey) 2,700 ppm
» BETA-SESQUIPHELLANDRENE (kgv)
» BIS-(PARA-HYDROXY-CINNAMOYL)-METHANE (kgv) 1,360 ppm
» BIS-DESMETHOXYCURCUMIN (kgv) 67-27,000 ppm
» BISABOLENE (Kök)
» BORNEOL (kgv)
» BORON (Kök) 1-6 ppm
» CAFFEIC-ACID (kgv) 5 ppm
» CAPRYLIC-ACID (kgv)
» CARBOHYDRATES (kgv) 79,000-829,000 ppm
» CARYOPHYLLENE (ey)
» ÇİNKO (kgv) 22 ppm
» CINEOLE (ey) 29,200 ppm
» CINNAMIC-ACID (kgv)
» COBALT (kgv) 1 ppm
» CUMINYL-ALCOHOL (kgv)
» CURCUMENE (ey) 121,700 ppm
» CURCUMENOL (ey) 21,300 ppm
» CURCUMIN (kgv) 9-38,888 ppm
» CURDIONE (ey) 11,900 ppm
» CURLONE (kgv) 120 ppm
» CURZERENONE (kgv)
» CURZERENONE-C (ey) 20,400 ppm
» CYCLO-ISOPRENEMYRCENE (kgv) 8,500-29,750 ppm
» D-ALPHA-PHELLANDRENE (kgv) 30-720 ppm
» D-CAMPHENE (kgv) 480 ppm
» D-CAMPHOR (kgv) 30-1,500 ppm
» D-SABINENE (kgv) 20-432 ppm
» DEHYDROTURMERONE (kgv)
» DEMİR (kgv) 121-467 ppm
» DESMETHOXYCURCUMIN (kgv) 500-11,100 ppm
» DI-P-COUMAROYL-METHANE (kgv)
» DICINNAMOYLMETHANE (kgv)
» DIDESMETHOXYCURCUMIN (kgv)
» DIDESMETHOXYCURCUMIN (kgv)
» DIFERULOYL-» METHANE (kgv)
» DIHYDROCURCUMIN (kgv) 57 ppm
» EO (kgv) 3,000-72,000 ppm
» EUGENOL (ey) 2,100 ppm
» FERULOYL-P-COUMAROYL-METHANE (kgv)
FOSFOR (kgv) 640-6,307 ppm
» FRUCTOSE (kgv) 120,000 ppm
» GAMMA-ATLANTONE (kgv)
» GLUCOSE (kgv) 280,000 ppm
» GUAIACOL (kgv)
» ISOBORNEOL (kgv) (ey) 200 ppm
» KROM (kgv) 6 ppm
» KALSİYUM(kgv) 270-2,898 ppm
» L-ALPHA-CURCUMENE (kgv) 18,000 ppm
» L-BETA-CURCUMENE (kgv) 18,000 ppm
» LIMONENE (ey) 2,300 ppm
» LİF(kgv) 9,000-84,000 ppm
» LINALOL (ey) 1,600 ppm
» MANGANESE (kgv) 33-78 ppm
» MONODESMETHOXYCURCUMIN (kgv)
» NIACIN (kgv) 5-62 ppm
» NICKEL (kgv) 3.8 ppm
» O-COUMARIC-ACID (yp)
» P-COUMARIC-ACID (kgv) 345 ppm
» P-CYMENE (kgv)
» P-METHOXYCINNAMIC-ACID (kgv) 360 ppm
» P-TOLYMETHYLCARBINOL (kgv) 500-1,750 ppm
» POTASSIUM (kgv) 4,870-41,271 ppm
» PROTEIN (kgv) 12,000-306,000 ppm
» PROTOCATECHUIC-ACID (yp)
» RESIN (kgv)
» RIBOFLAVIN (kgv) 0-12 ppm
» SODYUM (kgv) 30-4,290 ppm
» SU (kgv) 133,000 ppm
» SYRINGIC-ACID (yp)
» TERPINENE (ey) 27,200 ppm
» TERPINEOL (ey) 500 ppm
» THIAMIN (kgv) 0-8 ppm
» TURMERONE (kgv) 1,800-43,200 ppm
» UKONAN-A (kgv) 33-6,600 ppm
» UKONAN-B (kgv) 47 ppm
» UKONAN-C (kgv) 52 ppm
» UKONAN-D (kgv)
» VANILLIC-ACID (yp)
» YAÐ (kgv) 18,000-153,000 ppm
» ZINGIBERENE (kgv) 750-18,000 ppm
ppm = parts per million, tr = trace, (bt)= bitki, (ç)= çiçek, (ey)= esansiyal yağ, (kgv)= kök gövde, (th)= tohum, (yp)= yaprak
Çeşitli hastalıklarda zerdeçal
Antiioksidan/zerdeçal
Zerdeçal en etkin ve en yaygın kullanılan antioksidanlardan biridir(5-9).
Zerdeçal/enflamasyon
Yapılan araştırmalar zerdeçalın lökotirien, prostaglandin, tumor nekroze edici faktör ve interlökin-12 gibi iltihap oluşturan kimyasal maddelerin ortaya çıkışını geciktirip hafiflettiğini göstermiştir(10-11).
Solunum yolu enfeksiyonları/zerdeçal
Zerdeçal antienflamatuar ve antioksidan etkileri ile solunum yolu enfeksiyonlarınada (üst solunum yolu enfeksiyonu, astım, bronşit, sinüzit) yaygın olarak kullanılan bir halk ilacıdır.
Zerdeçal/kanser
Zerdeçalın aktif maddesi curcumin hem kanserin korunmasını sağlar hem de bazı kanserlerde tedavi edici olarak kullanılmıştır Tümör hücrelerinin üremesini engeller ve toksik yan ürünlerini azaltır (12-17).
Zerdaçal/Alzheimer
Zerdeçal antioksidan ve antienflamatuar etkileri ile Alzheimer hastalığına gidişi engellemektedir. Zerdeçalın beta-amiloid plaklarının gelişimini yavaşlattığı da gösterilmiştir (18-20).
Diğer hastalıklar
Zerdeçalın başta mültipl skleroz (21-22), katarakt oluşumu (23), karaciğer hasarı (24), enfarktüs(25) ve felç (26) olmak üzere çeşitli hastalıklar üzerine olumlu etkileri olduğuna ilişkin çok sayıda çalışma vardır.
Kaynaklar
1. Egan ME, Pearson P, Weiner SA, Rajendran V, Rubin D, Glöckner-Pagel J, Canny S, Du K, Lukacs GL, Caplan MJ. Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects Science, 2004; 304:600-602
2. Aydın A, Adal E. Kistik fibroz. İst Çocuk Kliniği Dergisi (Pediatri Arşivi) 1996; 3:308-13
3. Araujo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz. 2001 Jul;96(5):723-8.
4. http://www.bitki.org/index.php?bitki=curcuma%20longa
5. Miquel J, Bernd A, Sempere JM,Díaz-Alperi J, Ramírez A. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Archives of Gerontology and Geriatrics. 2002; 34(1): 37-46
6. Jitoe et al., 1992A. Jitoe, T. Masuda, I.G.P. Tengah, D.N. Suprapta, I.W. Gara and N. Nakatani , Antioxidant activity of tropical ginger extracts and analysis of the contained curcuminoids. J. Agric. Food Chem. 40 (1992), pp. 1337–1340.
7. Masuda et al., 1992T. Masuda, J. Isobe, A. Jitoe and N. Nakatani , Antioxidative curcuminoids from rhyzomes of Curcuma xantorrhyza. Phytochemistry 31 (1992), pp. 3645–3647. Abstract
8. Miquel J, Bernd A, Sempere JM,Díaz-Alperi J, Ramírez A. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Archives of Gerontology and Geriatrics. 2002; 34(1): 37-46
9. Ono K, Hasegawa K, Naiki H, Yamanda M. Curcumin has potent anti-amyloidogenic effects for Alzheimer’s beta-amyloid fibrils in vitro. J Neurosci Res. 2004 Mar 15; 75(6):742-50.
10. Skrzypezac-Jankun, N.P. McCabe, S.H. Selman and J. Jankun , Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence. Int. J. Mol. Med. 6 (2000), pp. 521–526.
11. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003 Feb;9(1):161-8.
12. Inano, M. Onoda, N. Inafuku, M. Kubota, Y. Kamada, T. Osawa, H. Kobayashi and K. Wakabayashi , Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis 21 (2000), pp. 1835–1841.
13. M.T. Huang, W. Ma, P. Yen, J.G. Xie, J. Han, K. Frenkel, D. Grunberger and A.H. Conney , Inhibitory effect of low doses of curcumin topical application on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis. Carcinogenesis 18 (1997), pp. 83–88.
14. Inano, M. Onoda, N. Inafuku, M. Kubota, Y. Kamada, T. Osawa, H. Kobayashi and K. Wakabayashi , Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis 21 (2000), pp. 1835–1841.
15. P. Limtrakul, S. Lipigorngoson, O. Namwong, A. Apisariyakul and F.W. Dunn , Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett. 116 (1997), pp. 197–203.
16. Van Erk MJ, Teuling E, Staal YCM et al. Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells. J Carcinog. 2004 May 12;3(1):8.
17. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003 Jan-Feb;23(1A):363-98.
18. Ambegaokar SS, Wu L, Alamshahi K, et al. Curcumin inhibits dose-dependently and time-dependently neuroglial cell proliferation and growth. Neuro Endocrinol Lett. 2003 Dec; 24(6): 469-73.
19. Frautschy SA, Hu W, Kim P, et al. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging. 2001 Nov; 22(6):993-1005.
20. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1;21(21):8370-7.
21. Natarajan C, Bright JJ. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J Immunol 2002;168(12):6506-13.
22. Natarajan C, Bright JJ. Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. Genes Immun 2002;3(2):59-70.
23. Padmaja S, Raju TN. Antioxidant effect of curcumin in selenium induced cataract of Wistar rats. Indian J Exp Biol. 2004;42(6):601-3.
24. Liu YG, Chen HC, Jiang YP. Protective effect of curcumin on experimental liver injury in mice. Zhongguo Zhong Yaho Za Zhi. 2003;28(8):756-8, 93.
25. Nirmala C, Puvanakrisnan R. Protective role of curcumin against isoproterenol induced myocardial infarction. Mol Cell Biochem. 1996 Jun 21;159(2):85-93.
26. Thiyagarajan M, Sharma SS. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sci. 2004 Jan 9;74(8):969-85.
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